The Game Walkthrough

You may find that you will want to repair your weapons/armor at every available
opportunity. This is because weapons do a lot more damage when they are at 100%
condition or above, and armor is much more effective at protecting you when it is in good condition. When you are a master of the "armorer" skill, you can repair your items to above 100% which means weapons do even more damage and armor is even more effective at protecting you.

As well as Oblivion, Fallout 3 can be modded if you own the PC version of the game. You can do anything from adding armor/weapons to adding a new quest. you will find that there are several websites devoted to this. There are also several tutorials on video hosting websites such as Youtube.

Make use of Vats - If you find that you have poor aim, then use the VATS system!
If you are close to your enemy the VATS aiming is very accurate and powerful, and you will find that it seldom requires more than one bullet to kill your enemy.

If you are one for exploring, then simply wander throughout the Wasteland and
intercept bandits/camps etc. and you will find that they will sometimes have some
interesting stuff. There is also a secret location in the North of the wasteland where you can get your hands on a special plasma weapon...

You will find that throughout the game ammunition, is scarce - Make use of melee
weapons as much as possible and if you do use your guns, then aim for the head using VATS so you use as little ammunition as possible.

This is the first major boss that you will encounter. If you are on medium difficulty or below, you should not find him too hard. However, on Hard, unless you have a effective stratergy, he will wipe the floor with you. Here are some tips:

- Hack the Healing Stations - When he has low health, he will attempt to heal at a nearby healing station. To solve this, simply hack it. This will cause the good doctor to loose some health as well as rendering him immobile for a while.

- You can use telekinesis to take one of the nearby oxygen tanks and throwing it at him - This can cause a substantial amount of damage and also render him immobile for a short period of time.

- Keep Moving - If you do not keep moving, he will simply shoot you and hit you with his powerful Tommy-gun and you will find yourself being revived in a Vita Chamber if you're not careful.

Finally. The hardest way. The most boring and time consuming way. If you have no decent items, no armor-piercing bullets and no money, then here is a way to defeat the daddies. Quite Simply, find the daddy, and hit it with your wrench. As much as you can. Until you die. Once you have died, you will be revived in a nearby Vita Chamber. Simply find the Daddy again, and carry on where you left off. This method is time consuming, as well as boring as hell, but it does get the job done. Eventually. Note, this is very ineffective on Hard difficulty.