Bioshock - Big Daddies Part 1

You will find that unless you are on the easy difficulty, Big Daddies are actually rather hard to kill. Here is one stratergy that can be employed against them:

- Use Proximity Mines: Attack a Big Daddy with a long ranged weapon, just so it is following you. Then, run away from it, dropping proximity mines as you go. If you need time to reload, you could try shocking or freezing it to buy you some time.